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PLAC (LP-PLA2) Blood Test Kit

£120 ✓ In Stock

What's covered in the price: Laboratory-supplied test kit with sample collection materials and prepaid return packaging. Results turnaround varies by test — see the estimated turnaround time shown above.
Results ready within 3 working days

Your sample goes to a UKAS accredited laboratory meeting ISO 15189 standards.

Date of birth required

After you receive your order confirmation email, please reply with your date of birth.

Blood sample
Clinic visit
(phlebotomy charges apply)
CQC registered Accredited UK labs ISO 15189

How it works

Your testing journey

From order to results in four simple steps. Full transparency on where each step happens and what it costs.

1
Medi Test Direct kit delivered by post

Receive your kit by post

Dispatched same working day if ordered before 3pm. Royal Mail Tracked delivery, typically 1–3 working days. 90% of kits arrive within 24 hours.

2
Clinic sample collection

Visit a partner clinic

Book a phlebotomy appointment at one of our 365+ UK partner clinics. Take your kit with you — the phlebotomist will collect your sample using the materials provided.

Phlebotomy fee applies (paid at clinic)
3
Venous blood draw at a clinic

Venous blood draw at a clinic

A trained phlebotomist takes a small blood sample from a vein in your arm using the vacutainers provided in your kit. The appointment takes around 10 minutes.

4
Return sample by prepaid envelope

Return by prepaid envelope

Seal your sample in the biohazard bag provided and drop it in any Royal Mail postbox using the prepaid Tracked 24 envelope. Post Monday–Thursday for best results.

Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as the PLAC test, measures an enzyme that plays a key role in arterial inflammation and the development of atherosclerotic plaque. Unlike standard cholesterol tests, Lp-PLA2 is produced directly within arterial plaques, making it a specific marker for vascular inflammation and unstable plaque—the type most likely to rupture and cause heart attacks or strokes.

This test is ideal for individuals concerned about cardiovascular health, those with a family history of heart disease or stroke, people with borderline or elevated cholesterol who want deeper insight into their risk, and anyone who has already had a cardiovascular event and wants to monitor their ongoing risk. The PLAC test provides information beyond standard lipid panels, helping to identify "hidden" cardiovascular risk in people whose cholesterol levels appear normal.

What's covered in the price: You receive a venous blood collection kit and professional laboratory analysis. Because this test requires a venous blood draw, you'll need to arrange collection with a qualified phlebotomist—either at a clinic near you or through your own arrangements. A phlebotomy fee may apply separately. Your results will be ready within 3 working days.

Venous Blood Collection Kit

This kit is sent to you and taken to your chosen clinic. The phlebotomist will collect your sample using the materials provided.

  1. 1Vacutainer blood collection tubes
  2. 2Needle and butterfly needle
  3. 3Tourniquet
  4. 4Alcohol swab
  5. 5Cotton wool and gauze
  6. 6Adhesive plaster
  7. 7Biohazard specimen bag
  8. 8Prepaid return envelope (Royal Mail Tracked 24)
  9. 9Laboratory request form
  10. 10Instructions for the phlebotomist
Fasting: No fasting is required for this test. You can eat and drink normally before your blood draw. Timing: This test can be taken at any time of day. Lp-PLA2 levels are relatively stable and not significantly affected by recent meals. Medications: Continue taking your regular medications as prescribed, including statins or other cholesterol-lowering medications. Inform your healthcare provider about all medications you're taking when discussing your results, as some treatments may affect Lp-PLA2 levels. Recent Illness: If you've recently been unwell with an infection or other acute illness, consider waiting 2-3 weeks after recovery before testing, as acute inflammation can temporarily affect results. Test Limitations: This test does not diagnose heart disease but identifies vascular inflammation that may contribute to cardiovascular risk. Results should be interpreted alongside other cardiovascular markers including lipid panel, hs-CRP, and clinical risk factors. A single elevated result does not confirm disease—discuss your results with your healthcare provider.

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme produced by inflammatory cells within atherosclerotic plaques in artery walls. It plays a direct role in vascular inflammation by generating pro-inflammatory and cytotoxic products that destabilise plaques, making them more likely to rupture. This makes Lp-PLA2 a specific marker for vascular inflammation and vulnerable plaque. Unlike hs-CRP, which reflects general systemic inflammation from any source, Lp-PLA2 is produced predominantly within arterial plaques themselves, making it more specific to cardiovascular risk. Studies have shown that elevated Lp-PLA2 is associated with approximately doubled risk of coronary heart disease and stroke, independent of traditional risk factors including LDL cholesterol. The PLAC test is FDA-cleared as an aid in assessing risk of coronary heart disease and ischaemic stroke. Elevated Lp-PLA2 levels (generally above 200 ng/mL or 235 nmol/min/mL depending on assay method) indicate increased vascular inflammation and may warrant more aggressive cardiovascular risk management. Lifestyle modifications (diet, exercise, smoking cessation) and certain medications (particularly statins) can lower Lp-PLA2 levels over time. Results should be discussed with your GP or cardiologist, who can interpret them in the context of your overall cardiovascular risk profile.

Medical Disclaimer

This test is for screening and information only — it is not a medical diagnosis or professional advice. Please have your results reviewed by a qualified doctor or healthcare provider who can explain what they mean for your personal health situation. If your results show anything outside the normal range, or if you're worried about your health, see your doctor as soon as you can. Don't change any medications or treatments based on these results alone — always talk to your healthcare provider first.

NO CLINICS, NO QUEUES, NO HASSLE

Four steps to clarity

Pick your panel 01

Pick your panel

Browse over 200 clinically designed test kits and choose the one that fits your goals.

Kit to your door 02

Kit to your door

Everything you need arrives in discreet packaging with step-by-step instructions inside.

Collect your sample 03

Collect your sample

Follow the simple instructions in your kit — whether it's a finger-prick at home or a venous draw at a partner clinic.

Insights delivered 04

Insights delivered

Clear, easy-to-understand results sent to you online with actionable health guidance.

Frequently asked questions

If triglycerides included, fast 8-12 hours. For cardiac markers like BNP or Lp(a), fasting is not required. Drink water normally.

LP-PLA2 (lipoprotein-associated phospholipase A2) is an enzyme associated with vascular inflammation and unstable arterial plaques. Elevated levels indicate higher risk of cardiovascular events, independent of cholesterol levels.

Both measure cardiovascular-related inflammation, but LP-PLA2 is more specific to vascular inflammation. CRP rises with any inflammation (infections, injury, autoimmune). LP-PLA2 is more specifically linked to arterial plaque instability.

Normal results: every 3-5 years. On statins or with risk factors: every 6-12 months.

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